Dr Mabuya started her medical career in 1991 at the Chris Hani Baragwanath Hospital. In 1993 she went into private practice as a GP in Randfontein. In 2000 Dr Mabuya became an Occupational Health and Safety Consultant for a number of large corporations and unlisted companies, including Vodacom, Deloitte, Standard Bank of SA, Telkom and the South African Reserve Bank.